Which receptor does dexmedetomidine have affinity for?

Which receptor does dexmedetomidine have affinity for?

• A. A1 agonist
• B. B2 agonist
• C. A2 agonist
• D. NMDA receptor antagonist

Answer: (C)

Dexmedetomidine’s receptor selectivity is what this item tests. It is a highly selective alpha-2 adrenergic receptor agonist, meaning it preferentially binds to and activates alpha-2 receptors. This action reduces central sympathetic outflow, producing sedation and analgesia with minimal impact on respiration. It does not meaningfully engage alpha-1 receptors, beta receptors, or NMDA receptors. Alpha-1 agonists would cause vasoconstriction, beta-2 agonists affect bronchodilation and other smooth muscles, and NMDA receptor antagonists (like ketamine) produce a different anesthetic mechanism. So the receptor dexmedetomidine acts on is the alpha-2 adrenergic receptor.

Dexmedetomidine’s receptor selectivity is what this item tests. It is a highly selective alpha-2 adrenergic receptor agonist, meaning it preferentially binds to and activates alpha-2 receptors. This action reduces central sympathetic outflow, producing sedation and analgesia with minimal impact on respiration. It does not meaningfully engage alpha-1 receptors, beta receptors, or NMDA receptors. Alpha-1 agonists would cause vasoconstriction, beta-2 agonists affect bronchodilation and other smooth muscles, and NMDA receptor antagonists (like ketamine) produce a different anesthetic mechanism. So the receptor dexmedetomidine acts on is the alpha-2 adrenergic receptor.